From January 1986 to December 1992, reviewed 80 transitional cell carcinoma of bladder in the Department of Urology, Chungnam National University Hospital. DNA ploidy was analyzed with FCM(flow-cytometry) according to cellular differentiation,
tumor
stage, recurrence rate and invasiveness.
@ES The results are as followings:
@EN 1. Tumor grades were 8 cases in grade I, 30 cases in grade II, 38 cases in grade III and 4 cases in grade IV. And tumor stages were 45 cases in stage A, 28 cases in stage B, 5 cases in stage C and 2 cases in stage D.
2. In 80 transitional cell carcinoma of bladder, 41 tumors(51.2%) were diploid stem line, 39 tumors(48.8%) were aneuploid stem line. DNA ploidy according to tumor grade, incidence of aneuploid was 17%(1/8) in grade I, 23%(7/30) in grade II,
71%(27/38)
in grade III and 100%(4/4) in grade IV. The incidence of aneuploid was increased with tumor grading(low grade; 21.1%, high grade; 73.8%) (P<0.001). And DNA ploidy according to stage, incidence of aneuploid was 31.1%(14/45) in superficial
transitional
cell carcinoma of bladder group, and 71.4%(25/35) in invasive and metastatic transitional cell carcinoma of bladder group(P<0.001).
3. In superficial transitional bladder carcinoma, recurrence rates according to tumor grade were 2.55 in low grade group, 5.69 in high grade group(P<0.01), and recurrence rates according to the DNA ploidy were 2.38 in diploid group and 5.04 in
aneuploid group(P<0.05).
4. In recurred superficial transitional bladder carcinoma, invasion rates according to the cellular grade were 15.4%(2/13) in low grade group, 62.5%(5/8) in high grade group(P>0.05), and invasion rates according to the DNA ploidy were
16.7%(2/12)
in
diploid group and 55.6%(5/9) in aneuploid group(P>0.5).
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